Heterophyllin B

Modify Date: 2025-08-22 11:28:57

Heterophyllin B structure	Common Name	Heterophyllin B
	CAS Number	145459-19-4	Molecular Weight	778.937
	Density	1.3±0.1 g/cm3	Boiling Point	1159.7±65.0 °C at 760 mmHg
	Molecular Formula	C₄₀H₅₈N₈O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	655.1±34.3 °C

Use of Heterophyllin B

Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1].

Name	Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl)
Synonym	More Synonyms

Description	Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
In Vitro	Heterophyllin B (0-200 µM; 12-48 hours) reduces cell viability in the 75, 100 and 200 µM groups, has no effect on 5, 10, 25 and 50 µM groups[1]. Heterophyllin B (0-50 µM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells[1]. Cell Viability Assay[1] Cell Line: ECA-109 cells Concentration: 5 µM, 10 µM, 25 µM, 50 µM, 75 µM, 100 µM and 200 µM Incubation Time: 12, 24 and 48 hours Result: Decreased cell viability at high concentrations. Western Blot Analysis[1] Cell Line: ECA-109 cells Concentration: 0 µM, 10 µM, 25 µM, 50 µM Incubation Time: 6 hours Result: Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin.
References	[1]. Tantai JC, et al. Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling. Mol Med Rep. 2016 Feb;13(2):1097-104.

Density	1.3±0.1 g/cm3
Boiling Point	1159.7±65.0 °C at 760 mmHg
Molecular Formula	C₄₀H₅₈N₈O₈
Molecular Weight	778.937
Flash Point	655.1±34.3 °C
Exact Mass	778.437744
PSA	223.88000
LogP	-1.82
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.604
InChIKey	KYAVLJJQNUHRMR-PPLFBOPFSA-N
SMILES	CCC(C)C1NC(=O)C2CCCN2C(=O)C2CCCN2C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)CNC(=O)CNC(=O)C(Cc2ccccc2)NC1=O

Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl)

Heterophyllin B

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Heterophyllin B
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Heterophyllin B
Price: ￥2558.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Heterophyllin B
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥500/1 mg

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