BIBN-99

Modify Date: 2024-03-03 08:57:43

BIBN-99 structure	Common Name	BIBN-99
	CAS Number	145301-48-0	Molecular Weight	568.15000
	Density	1.172g/cm3	Boiling Point	709.8ºC at 760mmHg
	Molecular Formula	C₃₁H₄₂ClN₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	383.1ºC

Use of BIBN-99

BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].

Name	N-[3-[1-[2-(8-chloro-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]piperidin-4-yl]propyl]-N-ethyl-2,2-dimethylpentanamide

Description	BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30. [2]. Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686(1):37-43.

Description

BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].

Related Catalog

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

References

[1]. Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30.

[2]. Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686(1):37-43.

Density	1.172g/cm3
Boiling Point	709.8ºC at 760mmHg
Molecular Formula	C₃₁H₄₂ClN₅O₃
Molecular Weight	568.15000
Flash Point	383.1ºC
Exact Mass	567.29800
PSA	89.34000
LogP	5.95490
Vapour Pressure	5.35E-20mmHg at 25°C
Index of Refraction	1.561

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BIBN-99

Use of BIBN-99

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BIBN-99 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.