BIBN-99

Names

[ CAS No. ]:
145301-48-0

[ Name ]:
BIBN-99

Biological Activity

[Description]:

BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Neurological Disease

[References]

[1]. Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30.  

[2]. Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686(1):37-43.  

Chemical & Physical Properties

[ Density]:
1.172g/cm3

[ Boiling Point ]:
709.8ºC at 760mmHg

[ Molecular Formula ]:
C31H42ClN5O3

[ Molecular Weight ]:
568.15000

[ Flash Point ]:
383.1ºC

[ Exact Mass ]:
567.29800

[ PSA ]:
89.34000

[ LogP ]:
5.95490

[ Vapour Pressure ]:
5.35E-20mmHg at 25°C

[ Index of Refraction ]:
1.561

Related Compounds

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