CYM 5520

Modify Date: 2024-01-08 16:39:51

CYM 5520 structure	Common Name	CYM 5520
	CAS Number	1449747-00-5	Molecular Weight	345.395
	Density	1.2±0.1 g/cm3	Boiling Point	580.5±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₉N₃O₂	Melting Point	N/A
	MSDS	USA	Flash Point	304.9±30.1 °C
	Symbol	GHS05, GHS06	Signal Word	Danger

Use of CYM 5520

CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research[1][2].

Name	1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]-6-oxo-1,6-dihydro-3-pyridinecarbonitrile
Synonym	More Synonyms

Description	CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Metabolic Disease
In Vitro	CYM-5520 (EC50 of 1.6 μM) is a full agonist for wild type S1PR2. Stimulation of cells expressing the triple mutant S1PR2 with S1P does not elicit a rise in luciferase activity, whereas the CYM-5520 is an agonist with an EC50 of 1.5 μM[1].
In Vivo	CYM-5520 (10 mg/kg; i.p.; 5 consecutive days per week; for 6 weeks) treatment clearly increases long bone and vertebral bone mass in osteopenic ovariectomized mice. CYM-5520 also increases osteoblast number, osteoid surface and alkaline phosphatase, and plasma concentrations of the osteoanabolic marker procollagen I C-terminal propeptide are also elevated[2]. Animal Model: Ovariectomized 12 weeks old C57Bl6J mice[2] Dosage: 10 mg/kg Administration: i.p.; 5 consecutive days per week; for 6 weeks Result: Corrected ovariectomy-induced osteopenia in mice by inducing new bone formation.
References	[1]. Hideo Satsu, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013 Sep 1;21(17):5373-82. [2]. Sarah Weske, et al. Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice. Bone. 2019 Aug;125:1-7.

Density	1.2±0.1 g/cm3
Boiling Point	580.5±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₉N₃O₂
Molecular Weight	345.395
Flash Point	304.9±30.1 °C
Exact Mass	345.147736
LogP	2.52
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.611
Storage condition	2-8°C

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301-H318
Precautionary Statements	P280-P301 + P310-P305 + P351 + P338
Risk Phrases	25-41
Safety Phrases	26-39-45
RIDADR	UN 2811 6.1 / PGIII

3-Pyridinecarbonitrile, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-

MFCD28100815

1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]-6-oxo-1,6-dihydro-3-pyridinecarbonitrile

CYM-5520

DC Chemicals Limited
China
Product Name: CYM-5520
Price: ￥Inquiry/100mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

CYM 5520 suppliers

Price: ￥1300/10 mM * 1 mL in DMSO

Reference only. check more CYM 5520 price

CYM 5520

Use of CYM 5520

Names

CYM 5520 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms