1355026-60-6
1355026-60-6 structure
- Name: CYM 50260
- Chemical Name: cym50260
- CAS Number: 1355026-60-6
- Molecular Formula: C14H11Cl3FNO2
- Molecular Weight: 350.60000
- Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
- Create Date: 2017-12-09 20:43:16
- Modify Date: 2024-01-02 19:09:48
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CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].
| Name | cym50260 |
|---|
| Description | CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 45 nM (S1P4-R)[1] |
| In Vitro | CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2]. |
| References |
| Molecular Formula | C14H11Cl3FNO2 |
|---|---|
| Molecular Weight | 350.60000 |
| Exact Mass | 348.98400 |
| PSA | 31.35000 |
| LogP | 4.96910 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |