Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P 4-R) agonists

…, M Urbano, J Zhao, M Crisp, P Chase, P Hodder…

Index: Guerrero, Miguel; Urbano, Mariangela; Zhao, Jian; Crisp, Melissa; Chase, Peter; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic and Medicinal Chemistry Letters, 2012 ,  vol. 22,  # 1  p. 537 - 542

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Citation Number: 11

Abstract

High affinity and selective small molecule agonists of the S1P4 receptor (S1P4-R) may have significant therapeutic utility in diverse disease areas including autoimmune diseases, viral infections and thrombocytopenia. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 3-(2-(2, 4-dichlorophenoxy) ethoxy)-6- methyl-2-nitropyridine as a moderately potent and selective S1P4-R hit agonist. Design, ...