CYM 50308
Modify Date: 2025-08-22 08:07:28
CYM 50308 structure
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Common Name | CYM 50308 | ||
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| CAS Number | 1345858-76-5 | Molecular Weight | 405.461 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 504.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H21F2N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 258.6±32.9 °C | |
Use of CYM 50308CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1]. |
| Name | (2Z,5Z)-5-{[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]me thylene}-2-[(2-methoxyethyl)imino]-3-methyl-1,3-thiazolidin-4-one |
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| Synonym | More Synonyms |
| Description | CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1]. |
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| Related Catalog | |
| Target |
EC50: 56 nM (S1P4-R), 2100 nM (S1P5-R)[1] |
| In Vitro | The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 504.0±60.0 °C at 760 mmHg |
| Molecular Formula | C20H21F2N3O2S |
| Molecular Weight | 405.461 |
| Flash Point | 258.6±32.9 °C |
| Exact Mass | 405.132263 |
| PSA | 72.13000 |
| LogP | 3.29 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.594 |
| InChIKey | BKQZKTRCUAWRHT-ONBPWHQPSA-N |
| SMILES | COCCN=C1SC(=Cc2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1C |
| SIB 1553A hydrochloride |
| 4-Thiazolidinone, 5-[[1-(2,4-difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-, (2Z,5Z)- |
| (2Z,5Z)-5-{[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-[(2-methoxyethyl)imino]-3-methyl-1,3-thiazolidin-4-one |