p38-α MAPK-IN-5

Modify Date: 2025-11-02 21:34:36

p38-α MAPK-IN-5 Structure
p38-α MAPK-IN-5 structure
Common Name p38-α MAPK-IN-5
CAS Number 1443242-46-3 Molecular Weight 679.86
Density N/A Boiling Point N/A
Molecular Formula C37H49N11O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of p38-α MAPK-IN-5


p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

 Names

Name p38-α MAPK-IN-5

 p38-α MAPK-IN-5 Biological Activity

Description p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
Related Catalog
Target

p38α:0.1 nM (IC50)

p38β:0.2 nM (IC50)

p38γ:944 nM (IC50)

p38δ:4100 nM (IC50)

References

[1]. Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.

 Chemical & Physical Properties

Molecular Formula C37H49N11O2
Molecular Weight 679.86
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