1006378-90-0

1006378-90-0 structure

Name: p38 MAPK-IN-1
Chemical Name: p38 MAPK-IN-1
CAS Number: 1006378-90-0
Molecular Formula: C₂₁H₁₅F₂N₂O
Molecular Weight: 349.35
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-02-14 22:52:49
Modify Date: 2025-08-29 17:10:32
p38 MAPK-IN-1 is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.

Name	p38 MAPK-IN-1
Synonyms	1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide 4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine 7-oxide

Description	p38 MAPK-IN-1 is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Cancer
References	[1]. Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910.