443913-15-3

443913-15-3 structure

Name: p38-α MAPK-IN-1
Chemical Name: p38-α MAPK-IN-1
CAS Number: 443913-15-3
Molecular Formula: C₂₇H₃₅N₅O₃
Molecular Weight: 477.6
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-07-16 13:09:28
Modify Date: 2024-01-10 17:40:21
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

Name	p38-α MAPK-IN-1

Description	p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Others
Target	IC50: 2300 nM (p38-α, in EFC assay), 5500 nM (p38-α, in HTRF assay)[1]
In Vitro	p38-α MAPK-IN-1 (Compound 12) is an inhibitor of MAPK14 (p38-α)>, with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].
References	[1]. Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67.