CB1-IN-1
Modify Date: 2024-01-11 11:31:05
CB1-IN-1 structure
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Common Name | CB1-IN-1 | ||
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| CAS Number | 1429239-98-4 | Molecular Weight | 751.669 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C33H31Cl2F3N6O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CB1-IN-1CB1-IN-1 is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively.IC50 value: 0.3 nM (Ki, CB1R) 21 nM (Ki, CB2R)Target: CB1Rin vivo: CB1-IN-1 is a novel peripherally restricted cannabinoid 1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. CB1-IN-1 has great potential to ameliorate this related metabolic syndrome. |
| Name | 1-(2,4-Dichlorophenyl)-N-(1-piperidinyl)-4-{[(1-pyrrolidinylsulfonyl)amino]methyl}-5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}-2-thienyl)-1H-pyrazole-3-carboxamide |
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| Synonym | More Synonyms |
| Description | CB1-IN-1 is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively.IC50 value: 0.3 nM (Ki, CB1R) 21 nM (Ki, CB2R)Target: CB1Rin vivo: CB1-IN-1 is a novel peripherally restricted cannabinoid 1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. CB1-IN-1 has great potential to ameliorate this related metabolic syndrome. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C33H31Cl2F3N6O3S2 |
| Molecular Weight | 751.669 |
| Exact Mass | 750.122803 |
| LogP | 6.52 |
| Index of Refraction | 1.672 |
| Storage condition | 2-8℃ |
| 1-(2,4-Dichlorophenyl)-N-(1-piperidinyl)-4-{[(1-pyrrolidinylsulfonyl)amino]methyl}-5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}-2-thienyl)-1H-pyrazole-3-carboxamide |
| 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]- |
| CB1-IN-1 |