1-N-Boc-3-hydroxyazetidine

Modify Date: 2025-08-22 06:59:34

1-N-Boc-3-hydroxyazetidine Structure
1-N-Boc-3-hydroxyazetidine structure
 Common Name 1-N-Boc-3-hydroxyazetidine
CAS Number 141699-55-0 Molecular Weight 173.210
Density 1.2±0.1 g/cm3 Boiling Point 253.7±33.0 °C at 760 mmHg
Molecular Formula C8H15NO3 Melting Point 42-44°C
MSDS Chinese USA Flash Point 107.2±25.4 °C
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Use of 1-N-Boc-3-hydroxyazetidine


1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

 Names

Name 1-Boc-3-hydroxyazetidine
Synonym More Synonyms

 1-N-Boc-3-hydroxyazetidine Biological Activity

Description 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 253.7±33.0 °C at 760 mmHg
Melting Point 42-44°C
Molecular Formula C8H15NO3
Molecular Weight 173.210
Flash Point 107.2±25.4 °C
Exact Mass 173.105194
PSA 49.77000
LogP -0.17
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.511
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi,Xn
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-N-Boc-3-hydroxyazetidine
1-(tert-Butoxycarbonyl)-3-hydroxyazetidine
MFCD04115305
tert-Butyl 3-Hydroxyazetidine-1-carboxylate
3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester
1-BOC-3-Hydroxyazetidine
N-Boc-3-hydroxyazetidine
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