Name | 1-Boc-3-hydroxyazetidine |
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Synonyms |
1-N-Boc-3-hydroxyazetidine
1-(tert-Butoxycarbonyl)-3-hydroxyazetidine MFCD04115305 tert-Butyl 3-Hydroxyazetidine-1-carboxylate 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester 1-BOC-3-Hydroxyazetidine N-Boc-3-hydroxyazetidine |
Description | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs |
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Related Catalog | |
Target |
Non-cleavable |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 253.7±33.0 °C at 760 mmHg |
Melting Point | 42-44°C |
Molecular Formula | C8H15NO3 |
Molecular Weight | 173.210 |
Flash Point | 107.2±25.4 °C |
Exact Mass | 173.105194 |
PSA | 49.77000 |
LogP | -0.17 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.511 |
Storage condition | 2-8°C |
Symbol |
GHS05, GHS07 |
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Signal Word | Danger |
Hazard Statements | H302-H315-H318-H335 |
Precautionary Statements | P261-P280-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi,Xn |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
HS Code | 2933990090 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |