- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 1-N-Boc-3-hydroxyazetidine
- Price: Check
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 1-N-Boc-3-hydroxyazetidine
- Price: ￥308.0/5g ￥88.0/1g
- Purity: 97.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Email: 2130147988@qq.com
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: 1-N-Boc-3-hydroxyazetidine
- Price: ￥6000.0/1kg
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Lihua Yang
- Email: sales@pu-kang.com
- DC Chemicals Limited
- China
- Product Name: 1-N-Boc-3-hydroxyazetidine
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-N-Boc-3-hydroxyazetidine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
141699-55-0
141699-55-0 structure
- Name: 1-N-Boc-3-hydroxyazetidine
- Chemical Name: 1-Boc-3-hydroxyazetidine
- CAS Number: 141699-55-0
- Molecular Formula: C8H15NO3
- Molecular Weight: 173.210
- Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Cyclic hydrocarbon
- Create Date: 2018-07-04 09:56:40
- Modify Date: 2025-08-22 06:59:34
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1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
| Name | 1-Boc-3-hydroxyazetidine |
|---|---|
| Synonyms |
1-N-Boc-3-hydroxyazetidine
1-(tert-Butoxycarbonyl)-3-hydroxyazetidine MFCD04115305 tert-Butyl 3-Hydroxyazetidine-1-carboxylate 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester 1-BOC-3-Hydroxyazetidine N-Boc-3-hydroxyazetidine |
| Description | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 253.7±33.0 °C at 760 mmHg |
| Melting Point | 42-44°C |
| Molecular Formula | C8H15NO3 |
| Molecular Weight | 173.210 |
| Flash Point | 107.2±25.4 °C |
| Exact Mass | 173.105194 |
| PSA | 49.77000 |
| LogP | -0.17 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.511 |
| Storage condition | 2-8°C |
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi,Xn |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
![3-[4-(trifluoromethyl)phenoxy]azetidine structure](https://image.chemsrc.com/caspic/406/76263-21-3.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |