LUF7244
Modify Date: 2024-04-13 17:12:37
LUF7244 structure
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Common Name | LUF7244 | ||
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| CAS Number | 1416575-97-7 | Molecular Weight | 366.801 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H15ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LUF7244A novel negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM); significantly decreases the Kv11.1 affinities of typical blockers (ie, dofetilide, astemizole, sertindole, and cisapride); prevents astemizole or sertindole caused heterogeneous prolongation of action potential duration in neonatal rat ventricular myocyte, with no effect on their viability, excitability and contractility. |
| Name | LUF7244 |
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| Description | A novel negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM); significantly decreases the Kv11.1 affinities of typical blockers (ie, dofetilide, astemizole, sertindole, and cisapride); prevents astemizole or sertindole caused heterogeneous prolongation of action potential duration in neonatal rat ventricular myocyte, with no effect on their viability, excitability and contractility. |
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| References | References 1. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel |
| Molecular Formula | C20H15ClN2O3 |
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| Molecular Weight | 366.801 |