1416575-97-7
1416575-97-7 structure
- Name: LUF7244
- Chemical Name: LUF7244
- CAS Number: 1416575-97-7
- Molecular Formula: C20H15ClN2O3
- Molecular Weight: 366.801
- Create Date: 2020-01-12 13:49:49
- Modify Date: 2024-04-13 17:12:37
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A novel negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM); significantly decreases the Kv11.1 affinities of typical blockers (ie, dofetilide, astemizole, sertindole, and cisapride); prevents astemizole or sertindole caused heterogeneous prolongation of action potential duration in neonatal rat ventricular myocyte, with no effect on their viability, excitability and contractility.
| Name | LUF7244 |
|---|
| Description | A novel negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM); significantly decreases the Kv11.1 affinities of typical blockers (ie, dofetilide, astemizole, sertindole, and cisapride); prevents astemizole or sertindole caused heterogeneous prolongation of action potential duration in neonatal rat ventricular myocyte, with no effect on their viability, excitability and contractility. |
|---|---|
| References | References 1. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel |
| Molecular Formula | C20H15ClN2O3 |
|---|---|
| Molecular Weight | 366.801 |