1821638-43-0
1821638-43-0 structure
- Name: LUF7244
- Chemical Name: LUF7244
- CAS Number: 1821638-43-0
- Molecular Formula: C20H15ClN2O3
- Molecular Weight: 366.80
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2022-09-16 13:50:31
- Modify Date: 2024-09-19 19:08:03
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LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research[1].
| Name | LUF7244 |
|---|
| Description | LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | LUF7244 (0-10 μM; HEK293 cells) binds Kv11.1 channels and increases IKv11.1 by inhibiting inactivation in a dose-dependent manner[1]. LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs[1]. LUF7244 (10 μM) had no effects on IKIR2.1, INav1.5, ICa-L, and IKs but doubled IKr[1]. |
| In Vivo | LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs[1]. |
| References |
| Molecular Formula | C20H15ClN2O3 |
|---|---|
| Molecular Weight | 366.80 |