LUF7244

A novel negative allosteric modulator of dofetilide binding to the Kv11.1 (hERG) channel with the strongest effect at 10 uM (IC50=3.9 uM); significantly decreases the Kv11.1 affinities of typical blockers (ie, dofetilide, astemizole, sertindole, and cisapride); prevents astemizole or sertindole caused heterogeneous prolongation of action potential duration in neonatal rat ventricular myocyte, with no effect on their viability, excitability and contractility.

References 1. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel