Mutant IDH1-IN-4
Modify Date: 2025-08-27 12:07:47
Mutant IDH1-IN-4 structure
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Common Name | Mutant IDH1-IN-4 | ||
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| CAS Number | 1416270-18-2 | Molecular Weight | 438.56246 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H34N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mutant IDH1-IN-4Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells[1]. |
| Name | (R)-8-cyclopropyl-6-(3-cyclopropyl-4-(3-methoxypropanoyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile |
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| Description | Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells[1]. |
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| Related Catalog | |
| Target |
IC50: ≤ 0.5 μM (mutant IDH 1 in cells)[1]. |
| References |
[1]. US20170210749A1. |
| Molecular Formula | C25H34N4O3 |
|---|---|
| Molecular Weight | 438.56246 |
| InChIKey | GNDMXEAGAZOBEM-NRFANRHFSA-N |
| SMILES | COCCC(=O)N1CCN(c2nc(C3CC3)c3c(c2C#N)CC(C)(C)OC3)CC1C1CC1 |