Mutant IDH1-IN-1
Modify Date: 2025-08-25 17:27:55
Mutant IDH1-IN-1 structure
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Common Name | Mutant IDH1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1355326-21-4 | Molecular Weight | 498.591 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C30H31FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mutant IDH1-IN-1Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. |
| Name | 2-(1H-Benzimidazol-1-yl)-N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. |
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| Related Catalog | |
| Target |
IC50: 4 nM (IDH1 R132C/R132C), 42 nM (IDH1 R132H/R132H), 80 nM (IDH1 R132H/WT), 143 nM (IDH1 wild type)[1] |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C30H31FN4O2 |
| Molecular Weight | 498.591 |
| Exact Mass | 498.243103 |
| LogP | 5.62 |
| Index of Refraction | 1.637 |
| InChIKey | DXYIOARJXVTYJW-UHFFFAOYSA-N |
| SMILES | Cc1ccccc1C(C(=O)NC1CCCCC1)N(C(=O)Cn1cnc2ccccc21)c1cccc(F)c1 |
| Storage condition | 2-8℃ |
| 2-(1H-Benzimidazol-1-yl)-N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)acetamide |
| 1H-Benzimidazole-1-acetamide, N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)- |
| Mutant IDH1-IN-1 |