1648909-73-2
1648909-73-2 structure
- Name: mutant IDH1 inhibitor VVS
- Chemical Name: Bis-Imidazole phenol IDH1 inhibitor
- CAS Number: 1648909-73-2
- Molecular Formula: C22H30N4O
- Molecular Weight: 366.500
- Create Date: 2020-01-14 12:31:06
- Modify Date: 2025-08-26 21:59:53
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mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.
| Name | Bis-Imidazole phenol IDH1 inhibitor |
|---|---|
| Synonyms |
2,6-Bis((1H-Imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
2,6-Bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethyl-2-pentanyl)phenol Phenol, 2,6-bis(1H-imidazol-1-ylmethyl)-4-(1,1,3,3-tetramethylbutyl)- 2,6-Bis(1h-Imidazol-1-Ylmethyl)-4-(2,4,4-Trimethylpentan-2-Yl)phenol Bis-Imidazole phenol IDH1 inhibitor |
| Description | mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line. |
|---|---|
| References | References 1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74. 2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159. View Related Products by Target Isocitrate Dehydrogenase (IDH) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 549.7±45.0 °C at 760 mmHg |
| Molecular Formula | C22H30N4O |
| Molecular Weight | 366.500 |
| Flash Point | 286.2±28.7 °C |
| Exact Mass | 366.241974 |
| LogP | 3.41 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.577 |
| RIDADR | NONH for all modes of transport |
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