2-Cyanopyrimidine

Modify Date: 2024-01-02 10:17:41

2-Cyanopyrimidine Structure
2-Cyanopyrimidine structure
Common Name 2-Cyanopyrimidine
CAS Number 14080-23-0 Molecular Weight 105.097
Density 1.2±0.1 g/cm3 Boiling Point 250.7±23.0 °C at 760 mmHg
Molecular Formula C5H3N3 Melting Point 40-44 °C(lit.)
MSDS Chinese USA Flash Point 97.2±7.8 °C
Symbol GHS06
GHS06
Signal Word Danger

 Use of 2-Cyanopyrimidine


2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].

 Names

Name 2-Cyanopyrimidine
Synonym More Synonyms

 2-Cyanopyrimidine Biological Activity

Description 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].
Related Catalog
Target

IC50: 170 nM (cysteine protease cathepsin K)[1]

In Vitro 2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].
References

[1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 250.7±23.0 °C at 760 mmHg
Melting Point 40-44 °C(lit.)
Molecular Formula C5H3N3
Molecular Weight 105.097
Flash Point 97.2±7.8 °C
Exact Mass 105.032700
PSA 49.57000
LogP -0.31
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.541

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H317
Precautionary Statements P280-P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R37/38;R41;R43
Safety Phrases S26-S36/37/39
RIDADR 3276
WGK Germany 3
HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

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 Synonyms

2-Cyanopyrimidine
NaMe: 2-CyanopyriMidine
Pyrimidin-2-carbonitril
2-Cynopyrimidine
2-CPY
pyrimidin-2-carbonitrile
MFCD00160513
2CPM
2-Pyrimidinecarbonitrile
Pyrimidine-2-carbonitrile
2-cyanpyrimidine
2-pyrimidinenitrile
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