2-Cyanopyrimidine

Names

[ Name ]:
2-Cyanopyrimidine

[Synonym ]:
2-Cyanopyrimidine
NaMe: 2-CyanopyriMidine
Pyrimidin-2-carbonitril
2-Cynopyrimidine
2-CPY
pyrimidin-2-carbonitrile
MFCD00160513
2CPM
2-Pyrimidinecarbonitrile
Pyrimidine-2-carbonitrile
2-cyanpyrimidine
2-pyrimidinenitrile

Biological Activity

[Description]:

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

IC50: 170 nM (cysteine protease cathepsin K)[1]

[In Vitro]

2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].

[References]

[1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
250.7±23.0 °C at 760 mmHg

[ Melting Point ]:
40-44 °C(lit.)

[ Molecular Formula ]:
C₅H₃N₃

[ Molecular Weight ]:
105.097

[ Flash Point ]:
97.2±7.8 °C

[ Exact Mass ]:
105.032700

[ PSA ]:
49.57000

[ LogP ]:
-0.31

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.541

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317

[ Precautionary Statements ]:
P280-P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R37/38;R41;R43

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
3276

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers.

Nat. Commun. 6 , 8580, (2015)

Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.