Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Cyanopyrimidine
Price: ￥198.0/25g ￥68.0/5g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 2-cyano-Pyrimidine
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Cyanopyrimidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-Cyanopyrimidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

14080-23-0

14080-23-0 structure

14080-23-0 structure

Name: 2-Cyanopyrimidine
Chemical Name: 2-Cyanopyrimidine
CAS Number: 14080-23-0
Molecular Formula: C₅H₃N₃
Molecular Weight: 105.097
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Cyanopyrimidine
Create Date: 2018-05-25 08:00:00
Modify Date: 2024-01-02 10:17:41
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].

Name	2-Cyanopyrimidine
Synonyms	2-Cyanopyrimidine NaMe: 2-CyanopyriMidine Pyrimidin-2-carbonitril 2-Cynopyrimidine 2-CPY pyrimidin-2-carbonitrile MFCD00160513 2CPM 2-Pyrimidinecarbonitrile Pyrimidine-2-carbonitrile 2-cyanpyrimidine 2-pyrimidinenitrile

Description	2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	IC50: 170 nM (cysteine protease cathepsin K)[1]
In Vitro	2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].
References	[1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4.

Density	1.2±0.1 g/cm3
Boiling Point	250.7±23.0 °C at 760 mmHg
Melting Point	40-44 °C(lit.)
Molecular Formula	C₅H₃N₃
Molecular Weight	105.097
Flash Point	97.2±7.8 °C
Exact Mass	105.032700
PSA	49.57000
LogP	-0.31
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.541

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H317
Precautionary Statements	P280-P301 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R37/38;R41;R43
Safety Phrases	S26-S36/37/39
RIDADR	3276
WGK Germany	3
HS Code	2933599090

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%