LAS191954

Modify Date: 2024-01-24 12:47:26

LAS191954 Structure
LAS191954 structure
Common Name LAS191954
CAS Number 1403947-26-1 Molecular Weight 397.393
Density 1.5±0.1 g/cm3 Boiling Point 769.0±70.0 °C at 760 mmHg
Molecular Formula C20H15N9O Melting Point N/A
MSDS N/A Flash Point 418.9±35.7 °C

 Use of LAS191954


LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].

 Names

Name 2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
Synonym More Synonyms

 LAS191954 Biological Activity

Description LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].
Related Catalog
Target

PI3Kδ:2.6 nM (IC50)

References

[1]. Erra M, et al. Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 769.0±70.0 °C at 760 mmHg
Molecular Formula C20H15N9O
Molecular Weight 397.393
Flash Point 418.9±35.7 °C
Exact Mass 397.139954
LogP 1.11
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.769

 Synonyms

2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
Pyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile, 2-[(1S)-1-[(6-amino-5-cyano-4-pyrimidinyl)amino]ethyl]-3,4-dihydro-4-oxo-3-phenyl-
MFCD28502110
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