1403947-26-1

1403947-26-1 structure

Name: LAS191954
Chemical Name: 2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
CAS Number: 1403947-26-1
Molecular Formula: C₂₀H₁₅N₉O
Molecular Weight: 397.393
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2018-07-10 18:15:56
Modify Date: 2024-01-24 12:47:26
LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].

Name	2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
Synonyms	2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile Pyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile, 2-[(1S)-1-[(6-amino-5-cyano-4-pyrimidinyl)amino]ethyl]-3,4-dihydro-4-oxo-3-phenyl- MFCD28502110

Description	LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology
Target	PI3Kδ:2.6 nM (IC50)
References	[1]. Erra M, et al. Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.