LAS191954

Names

[ Name ]:
LAS191954

[Synonym ]:
2-{(1S)-1-[(6-Amino-5-cyano-4-pyrimidinyl)amino]ethyl}-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile
Pyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile, 2-[(1S)-1-[(6-amino-5-cyano-4-pyrimidinyl)amino]ethyl]-3,4-dihydro-4-oxo-3-phenyl-
MFCD28502110

Biological Activity

[Description]:

LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Research Areas >> Inflammation/Immunology

[Target]

PI3Kδ:2.6 nM (IC50)

[References]

[1]. Erra M, et al. Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
769.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₅N₉O

[ Molecular Weight ]:
397.393

[ Flash Point ]:
418.9±35.7 °C

[ Exact Mass ]:
397.139954

[ LogP ]:
1.11

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.769

Related Compounds

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