ML 277
Modify Date: 2025-08-27 13:18:17
ML 277 structure
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Common Name | ML 277 | ||
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| CAS Number | 1401242-74-7 | Molecular Weight | 471.592 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H25N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 277ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.IC50 value: 270 nM (EC50) [1]Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel. |
| Name | (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide |
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| Synonym | More Synonyms |
| Description | ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.IC50 value: 270 nM (EC50) [1]Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C23H25N3O4S2 |
| Molecular Weight | 471.592 |
| Exact Mass | 471.128632 |
| PSA | 128.71000 |
| LogP | 4.68 |
| Index of Refraction | 1.631 |
| InChIKey | OXQNLLVUVDAEHC-OAQYLSRUSA-N |
| SMILES | COc1ccc(-c2csc(NC(=O)C3CCCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1 |
| Storage condition | 2-8℃ |
| (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide |
| 2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)- |
| ML-277 |
| ML277 |