Pentamidine isethionate

Modify Date: 2025-08-24 00:33:08

Pentamidine isethionate structure	Common Name	Pentamidine isethionate
	CAS Number	140-64-7	Molecular Weight	592.683
	Density	N/A	Boiling Point	539.4ºC at 760mmHg
	Molecular Formula	C₂₃H₃₆N₄O₁₀S₂	Melting Point	188-194 °C(lit.)
	MSDS	Chinese USA	Flash Point	280ºC
	Symbol	GHS07	Signal Word	Warning

Use of Pentamidine isethionate

Pentamidine isethionate is an antimicrobial agent for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.

Name	pentamidine isethionate
Synonym	More Synonyms

Description	Pentamidine isethionate is an antimicrobial agent for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Boiling Point	539.4ºC at 760mmHg
Melting Point	188-194 °C(lit.)
Molecular Formula	C₂₃H₃₆N₄O₁₀S₂
Molecular Weight	592.683
Flash Point	280ºC
Exact Mass	592.187256
PSA	284.16000
LogP	4.37750
Vapour Pressure	1.06E-11mmHg at 25°C
Storage condition	−20°C

Pentamidine isethionate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6500000

CHEMICAL NAME :: Benzamidine, 4,4'-(pentamethylenedioxy)di-, bis(beta-hydroxyethanesulfonate)

CAS REGISTRY NUMBER :: 140-64-7

LAST UPDATED :: 199603

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C19-H24-N4-O2.C4-H12-O8-S2

MOLECULAR WEIGHT :: 592.75

WISWESSER LINE NOTATION :: MUYZR DO5OR DYZUM &WSQ2Q 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 21429 ug/kg/5D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Skin and Appendages - sweating

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 24 mg/kg/6D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 68 mg/kg/17D-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 6 mg/kg/D

TOXIC EFFECTS :: Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 26 mg/kg/9D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15100 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 756 mg/kg/6W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 112 mg/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 24 mg/kg

SEX/DURATION :: female 6-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 29500 ug/L

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 1,103,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38;R43
Safety Phrases	S26-S36/37
RIDADR	3249
WGK Germany	3
RTECS	CV6500000
Packaging Group	III
Hazard Class	6.1(b)

ethyl 4-[5-[4-(...

CAS#:1252-44-4

Ammonium isethionate

CAS#:57267-78-4

~83%

Pentamidine ise...

CAS#:140-64-7

Literature: Nandi, Gopa; Mukherjee, S.; Basu, M. K.; Mahato, Shashi B. Journal of the Indian Chemical Society, 1993 , vol. 70, # 6 p. 527 - 532

Precursor 2
CAS#:1252-44-4 ethyl 4-[5-[4-(... CAS#:57267-78-4 Ammonium isethionate
DownStream 0

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.

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African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug toxicity and increasing drug resistance ...

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.

Planta Med. 76 , 365-8, (2010)

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquit...

Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro.

J. Neurosci. 12 , 970, (1992)

Acquired immunodeficiency syndrome (AIDS) is frequently associated with dementia. The wide spectrum of neurological abnormalities associated with this dementia may involve a neurotoxin that activates ...

4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide bis(2-hydroxyethanesulfonic acid)

2-Hydroxyethanesulfonic Acid compd. with 4,4'-(1,5-Pentanediylbis(oxy))bis(benzenecarboximidamide) (2:1)

2-Hydroxyethanesulfonic acid - 4,4'-[1,5-pentanediylbis(oxy)]dibenzenecarboximidamide (2:1)

Pentamidine isethionate salt

2-Hydroxyethanesulfonic acid - 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide (2:1)

4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)

MFCD00079213

Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,5-pentanediylbis(oxy)]bis[benzenecarboximidamide] (2:1)

EINECS 205-424-1

Pentamidine isethionate

4,4'-Diamidino-a,w-diphenoxypentane Isethionate

4,4â€²-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate)

Pentamidine diisetionate

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China
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China
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China
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DC Chemicals Limited
China
Product Name: Pentamidine Isethionate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pentamidine isethionate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Email: enquiry@dycnchem.com

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