D-threo-PPMP hydrochloride

Modify Date: 2024-01-09 13:00:36

D-threo-PPMP hydrochloride structure	Common Name	D-threo-PPMP hydrochloride
	CAS Number	139889-65-9	Molecular Weight	511.180
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₅₁ClN₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of D-threo-PPMP hydrochloride

D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].

Name	D-threo-PPMP (hydrochloride)
Synonym	More Synonyms

Description	D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	glucosylceramide synthase[1]
In Vitro	D-threo-PPMP (10 μM; 72 h) hydrochloride decreases the MDR1 expression by 70% in KB-V0.01 cells[1].
References	[1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. [2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. [3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.

Molecular Formula	C₂₉H₅₁ClN₂O₃
Molecular Weight	511.180
Exact Mass	510.358826

DL-threo-PPMP (hydrochloride)

N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]hexadecanamide hydrochloride (1:1)

Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)

D-threo-PPMP (hydrochloride)

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D-threo-PPMP hydrochloride

Use of D-threo-PPMP hydrochloride

Names

D-threo-PPMP hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.