139889-53-5

139889-53-5 structure

Name: D-threo-PPMP
Chemical Name: D-threo-1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol
CAS Number: 139889-53-5
Molecular Formula: C₂₉H₅₀N₂O₃
Molecular Weight: 474.72
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-22 13:45:30
Modify Date: 2024-02-08 18:33:15
D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production[1][2].

Name	D-threo-1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol
Synonyms	d-ppmp dl-ppmp ppmp D-threo-PPMP

Description	D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	glucosylceramide synthase[1]
In Vitro	D-threo-PPMP (10 μM; 72 h) decreases the MDR1 expression by 70% in KB-V0.01 cells[1].
References	[1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. [2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. [3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.