D-threo-PPMP hydrochloride

• 常用名: D-threo-PPMP hydrochloride
• 英文名: D-threo-PPMP hydrochloride
• CAS号: 139889-65-9
• 分子量: 511.180
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₅₁ClN₂O₃
• 熔点: N/A
• 闪点: N/A

D-threo-PPMP hydrochloride用途

D-苏氨酸-PPMP盐酸盐是葡萄糖神经酰胺(GlcCer)合酶的有效抑制剂。D-苏氨酸-PPMP盐酸盐可以阻断有丝分裂并减少囊肿的产生[1][2]。

D-threo-PPMP hydrochloride名称

• 英文名: D-threo-PPMP (hydrochloride)

D-threo-PPMP hydrochloride生物活性

• 描述: D-苏氨酸-PPMP盐酸盐是葡萄糖神经酰胺(GlcCer)合酶的有效抑制剂。D-苏氨酸-PPMP盐酸盐可以阻断有丝分裂并减少囊肿的产生[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 靶点:

  glucosylceramide synthase[1]

• 体外研究: D-苏氨酸-PPMP(10μM；72 h)盐酸盐可使KB-V0中的MDR1表达降低70%。01个细胞[1]。
• 参考文献:

  [1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7.

  [2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49.

  [3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.

D-threo-PPMP hydrochloride物理化学性质

• 分子式: C₂₉H₅₁ClN₂O₃
• 分子量: 511.180
• 精确质量: 510.358826
• InChIKey: ORVAUBQYJOFWFY-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)NC(CN1CCOCC1)C(O)c1ccccc1.Cl
• 储存条件: 2-8°C，密封，干燥

D-threo-PPMP hydrochloride英文别名

• DL-threo-PPMP (hydrochloride)
• N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]hexadecanamide hydrochloride (1:1)
• Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)
• D-threo-PPMP (hydrochloride)