Thiostrepton

Modify Date: 2025-08-20 11:44:02

Thiostrepton Structure
Thiostrepton structure
 Common Name Thiostrepton
CAS Number 1393-48-2 Molecular Weight 1664.89000
Density 1.64 g/cm3 Boiling Point N/A
Molecular Formula C72H85N19O18S5 Melting Point 248-257°C (dec.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Thiostrepton


Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.

 Names

Name thiostrepton
Synonym More Synonyms

 Thiostrepton Biological Activity

Description Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.
Related Catalog

 Chemical & Physical Properties

Density 1.64 g/cm3
Melting Point 248-257°C (dec.)
Molecular Formula C72H85N19O18S5
Molecular Weight 1664.89000
Exact Mass 1663.49000
PSA 701.00000
LogP 4.08640
Index of Refraction 1.768
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XN6300100
CHEMICAL NAME :
Thiostrepton
CAS REGISTRY NUMBER :
1393-48-2
LAST UPDATED :
199506
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C72-H85-N19-O18-S5
MOLECULAR WEIGHT :
1665.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,63,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),396,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),396,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),397,1980

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases 22
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XN6300100

 Articles32

More Articles
ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro.

Plant Mol. Biol. 78(1-2) , 185-96, (2012)

Chloroplasts possess common biosynthetic pathways for generating guanosine 3',5'-(bis)pyrophosphate (ppGpp) from GDP and ATP by RelA-SpoT homolog enzymes. To date, several hypothetical targets of ppGp...

Development of a vector and host system and characterization of replication of plasmid pSQ10 in moderately halophilic Nocardiopsis.

Acta Biochim. Biophys. Sin. (Shanghai) 43(9) , 738-43, (2011)

The genus of Nocardiopsis is a new source of antibiotics, chemicals, and enzymes. Here we reported the development of a vector and host system in moderately halophilic Nocardiopsis via an oriT-mediate...

Thiostrepton, proteasome inhibitors and FOXM1.

Cell Cycle 10(24) , 4341-2, (2011)

 Synonyms

MFCD00135828
Thiostrepton
EINECS 215-734-9
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Chemsrc provides Thiostrepton(CAS#:1393-48-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thiostrepton are included as well.>> amp version: Thiostrepton

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