iRGD peptide
Modify Date: 2024-01-07 09:34:17
iRGD peptide structure
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Common Name | iRGD peptide | ||
|---|---|---|---|---|
| CAS Number | 1392278-76-0 | Molecular Weight | 948.04 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H57N13O14S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of iRGD peptideiRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. |
| Name | iRGD peptide |
|---|
| Description | iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. |
|---|---|
| Related Catalog | |
| Target |
Integrin[1] |
| In Vitro | iRGD peptide-mediated tumor penetration occurs in three steps: binding to αv-integrins on tumor vasculature or tumor cells, exposure by proteolysis of a C-terminal motif that binds to neuropilin-1 (NRP-1) and cell internalization. iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells, which express NRP-1 and integrins. iRGD insertion does not impair virus infection and replication[1]. iRGD peptide alone has no obvious effect on gastric cancer cells, and when combined with 5-FU, iRGD peptide (0.3 μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1[2]. |
| In Vivo | iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2]. |
| Animal Admin | Mice[2] 12 male BALB/c nude mice (4-week-old) are assigned to 4 groups with 3 mice in each group. Among them,two groups are subcutaneously injected into the flanks by 3 × 106 HCG27 cells, the other two groups are conducted by NCI-N87 cells. Experimental groups are intravenously injected by 5-FU (25 mg/kg) mixed with iRGD peptide (4 mmol/kg) at every three days for 4 weeks while control groups are treated by 5-FU (25 mg/kg) mixed with PBS. And tumor volume is computed every 1 week with a digital vernier caliper using the following formula: tumor volume = (length × width2)/2[2]. |
| References |
| Molecular Formula | C35H57N13O14S2 |
|---|---|
| Molecular Weight | 948.04 |
| Storage condition | 2-8℃ |
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: iRGD peptide
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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Price: $647/10mM*1mL
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