Phox-I1
Modify Date: 2025-09-02 18:25:49
Phox-I1 structure
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Common Name | Phox-I1 | ||
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| CAS Number | 1388151-90-3 | Molecular Weight | 401.415 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 562.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C23H19N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 293.8±32.9 °C | |
Use of Phox-I1Phox-I1 is a small molecule inhibitor that targets the interactive site of p67(phox) with Rac GTPase with Kd of 100 nM; abrogates Rac1 binding and is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity. |
| Name | 9-Methoxy-5-(3-nitrophenyl)-2-phenyl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine |
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| Synonym | More Synonyms |
| Description | Phox-I1 is a small molecule inhibitor that targets the interactive site of p67(phox) with Rac GTPase with Kd of 100 nM; abrogates Rac1 binding and is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity. |
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| References | References 1. Bosco EE, et al. Chem Biol. 2012 Feb 24;19(2):228-42. View Related Products by Target Small GTPase |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.2±60.0 °C at 760 mmHg |
| Molecular Formula | C23H19N3O4 |
| Molecular Weight | 401.415 |
| Flash Point | 293.8±32.9 °C |
| Exact Mass | 401.137543 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.683 |
| InChIKey | VTKZDTUTWZFSRQ-UHFFFAOYSA-N |
| SMILES | COc1ccc2c(c1)C1CC(c3ccccc3)=NN1C(c1cccc([N+](=O)[O-])c1)O2 |
| 9-Methoxy-5-(3-nitrophenyl)-2-phenyl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine |
| 5H-Pyrazolo[1,5-c][1,3]benzoxazine, 1,10b-dihydro-9-methoxy-5-(3-nitrophenyl)-2-phenyl- |