Phox-I2
Modify Date: 2025-09-11 06:21:36
Phox-I2 structure
|
Common Name | Phox-I2 | ||
|---|---|---|---|---|
| CAS Number | 353495-22-4 | Molecular Weight | 337.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15N3O4 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Phox-I2Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1]. |
| Name | Phox-I2 |
|---|
| Description | Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 150 nM (p67phox)[1] |
| In Vitro | Phox-I2 可有效抑制 dHL-60 细胞和原代人中性粒细胞中 NOX2 介导的超氧化物产生，并具有剂量依赖性，且没有可检测到的细胞毒性[1]。 |
| References |
| Molecular Formula | C18H15N3O4 |
|---|---|
| Molecular Weight | 337.33 |
| Exact Mass | 337.10600 |
| PSA | 103.67000 |
| LogP | 5.51390 |
| InChIKey | PADQUVZDTGNTLH-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])c1cccc(C2Nc3ccc([N+](=O)[O-])cc3C3C=CCC32)c1 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H335 |
| Precautionary Statements | P261 |
| RIDADR | NONH for all modes of transport |