Phox-I1

Names

[ Name ]:
Phox-I1

[Synonym ]:
9-Methoxy-5-(3-nitrophenyl)-2-phenyl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
5H-Pyrazolo[1,5-c][1,3]benzoxazine, 1,10b-dihydro-9-methoxy-5-(3-nitrophenyl)-2-phenyl-

Biological Activity

[Description]:

Phox-I1 is a small molecule inhibitor that targets the interactive site of p67(phox) with Rac GTPase with Kd of 100 nM; abrogates Rac1 binding and is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity.

[References]

References 1. Bosco EE, et al. Chem Biol. 2012 Feb 24;19(2):228-42. View Related Products by Target Small GTPase

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
562.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₉N₃O₄

[ Molecular Weight ]:
401.415

[ Flash Point ]:
293.8±32.9 °C

[ Exact Mass ]:
401.137543

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds

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