PF-05241328

Modify Date: 2024-01-20 16:23:35

PF-05241328 Structure
PF-05241328 structure
Common Name PF-05241328
CAS Number 1387633-03-5 Molecular Weight 436.912
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C19H21ClN4O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PF-05241328


PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.

 Names

Name PF-05241328
Synonym More Synonyms

 PF-05241328 Biological Activity

Description PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.
Related Catalog
Target

IC50: 31 nM (Nav1.7)[1].

References

[1]. Jones HM, et al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55(7):875-887.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C19H21ClN4O4S
Molecular Weight 436.912
Exact Mass 436.097198
LogP 3.97
Index of Refraction 1.645
InChIKey RVTSXVZXEGFIPW-UHFFFAOYSA-N
SMILES Cc1nn(-c2cnc(OCC(C)C)c(Cl)c2)c2ccc(C(=O)NS(C)(=O)=O)cc12
Storage condition 2-8℃

 Synonyms

1-(5-Chloro-6-isobutoxy-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide
1H-Indazole-5-carboxamide, 1-[5-chloro-6-(2-methylpropoxy)-3-pyridinyl]-3-methyl-N-(methylsulfonyl)-
PF-05241328
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