GSK2647544

Modify Date: 2025-08-31 17:12:41

GSK2647544 Structure
GSK2647544 structure
Common Name GSK2647544
CAS Number 1380426-95-8 Molecular Weight 502.87
Density N/A Boiling Point N/A
Molecular Formula C24H18ClF3N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK2647544


GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].

 Names

Name GSK2647544

 GSK2647544 Biological Activity

Description GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].
Related Catalog
References

[1]. Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers
. Int J Clin Pharmacol Ther. 2016;54(12):935-949.

 Chemical & Physical Properties

Molecular Formula C24H18ClF3N4O3
Molecular Weight 502.87
InChIKey DRACNSAQZFZUKW-UHFFFAOYSA-N
SMILES O=c1[nH]c(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)ncc1Cc1cncnc1
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