1380426-95-8

1380426-95-8 structure

Name: GSK2647544
Chemical Name: GSK2647544
CAS Number: 1380426-95-8
Molecular Formula: C₂₄H₁₈ClF₃N₄O₃
Molecular Weight: 502.87
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2022-03-23 09:33:36
Modify Date: 2025-08-31 17:12:41
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].

Name	GSK2647544

Description	GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers . Int J Clin Pharmacol Ther. 2016;54(12):935-949.

Molecular Formula	C₂₄H₁₈ClF₃N₄O₃
Molecular Weight	502.87