GSK2647544

Names

[ Name ]:
GSK2647544

Biological Activity

[Description]:

GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers . Int J Clin Pharmacol Ther. 2016;54(12):935-949.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₈ClF₃N₄O₃

[ Molecular Weight ]:
502.87

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.