AI-2
Modify Date: 2025-08-25 11:08:55
AI-2 structure
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Common Name | AI-2 | ||
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| CAS Number | 1380107-92-5 | Molecular Weight | 342.779 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AI-2Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. |
| Name | AI-2 |
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| Description | Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. |
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| References | References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2 |
| Molecular Formula | C18H15ClN2O3 |
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| Molecular Weight | 342.779 |