AI-2

Names

[ Name ]:
AI-2

Biological Activity

[Description]:

Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

[References]

References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅ClN₂O₃

[ Molecular Weight ]:
342.779

Related Compounds

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