75483-04-4

75483-04-4 structure

Name: AI-1
Chemical Name: ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
CAS Number: 75483-04-4
Molecular Formula: C₁₃H₁₂ClNO₃
Molecular Weight: 265.69200
Create Date: 2017-06-08 21:33:01
Modify Date: 2025-08-26 00:20:24
Nrf2 acticatior AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.

Name	ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
Synonyms	ARE inducer-1 3-Quinolinecarboxylic acid,1,2-dihydro-4-chloro-1-methyl-2-oxo-,ethyl ester ethyl 1-methyl-4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate antioxidant response element inducer-1 1-methyl-2-oxo-4-chloroquinoline-3-carboxylic acid ethyl ester 4-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester 4-chloro-1-methyl-2-oxoquinoline-3-carboxylic acid ethyl ester ethyl 4-chloro-2-oxo-N-methyl-1,2-dihydroquinoline-3-carboxylate ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Density	1.34g/cm3
Boiling Point	358.7ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂ClNO₃
Molecular Weight	265.69200
Flash Point	170.7ºC
Exact Mass	265.05100
PSA	48.30000
LogP	2.36860
Index of Refraction	1.597

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
RIDADR	NONH for all modes of transport

57513-54-9

~87%

75483-04-4

Literature: Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054

10328-92-4

75483-04-4

Literature: Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722

105-53-3

75483-04-4

Literature: Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722

85-91-6

75483-04-4

Literature: Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054

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