AMPK activator SC4
Modify Date: 2025-09-18 20:11:19
AMPK activator SC4 structure
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Common Name | AMPK activator SC4 | ||
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| CAS Number | 1364692-88-5 | Molecular Weight | 471.897 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H18ClN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AMPK activator SC4AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. |
| Name | AMPK activator SC4 |
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| Description | AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. |
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| References | References 1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. View Related Products by Target AMPK |
| Molecular Formula | C26H18ClN3O4 |
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| Molecular Weight | 471.897 |