AMPK activator SC4

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

References 1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. View Related Products by Target AMPK