1364692-88-5
1364692-88-5 structure
- Name: AMPK activator SC4
- Chemical Name: AMPK activator SC4
- CAS Number: 1364692-88-5
- Molecular Formula: C26H18ClN3O4
- Molecular Weight: 471.897
- Create Date: 2020-01-12 09:33:50
- Modify Date: 2025-09-18 20:11:19
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AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
| Name | AMPK activator SC4 |
|---|
| Description | AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. |
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| References | References 1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. View Related Products by Target AMPK |
| Molecular Formula | C26H18ClN3O4 |
|---|---|
| Molecular Weight | 471.897 |