coluracetam
Modify Date: 2024-01-05 18:12:14
coluracetam structure
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Common Name | coluracetam | ||
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| CAS Number | 135463-81-9 | Molecular Weight | 341.404 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 634.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H23N3O3 | Melting Point | 225 °C | |
| MSDS | N/A | Flash Point | 337.3±31.5 °C | |
Use of coluracetamColuracetam(MKC-231) is a new choline uptake enhancer.IC50 value:Target:in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1].in vivo: Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested [2]. |
| Name | N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | Coluracetam(MKC-231) is a new choline uptake enhancer.IC50 value:Target:in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1].in vivo: Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested [2]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.1±55.0 °C at 760 mmHg |
| Melting Point | 225 °C |
| Molecular Formula | C19H23N3O3 |
| Molecular Weight | 341.404 |
| Flash Point | 337.3±31.5 °C |
| Exact Mass | 341.173950 |
| PSA | 75.44000 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.641 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2942000000 |
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro(2,3-b)quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide |
| N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide |
| Coluracetam [INN] |
| coluracetam |
| 1-Pyrrolidineacetamide, 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)- |
| N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide |
| UNII-V6FL6O5GR7 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
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- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: COLURACETAM
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
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- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: CAS135463-81-9 COLURACETAM
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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