Fmoc-L-cysteine

Modify Date: 2024-01-08 19:33:06

Fmoc-L-cysteine structure	Common Name	Fmoc-L-cysteine
	CAS Number	135248-89-4	Molecular Weight	343.397
	Density	1.3±0.1 g/cm3	Boiling Point	574.4±50.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₇NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	301.2±30.1 °C

Use of Fmoc-L-cysteine

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-cysteine is a cysteine derivative[1].

Name	(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-sulfanylpropanoic acid
Synonym	More Synonyms

Description	(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-cysteine is a cysteine derivative[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References	[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807.

Density	1.3±0.1 g/cm3
Boiling Point	574.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₇NO₄S
Molecular Weight	343.397
Flash Point	301.2±30.1 °C
Exact Mass	343.087830
PSA	114.43000
LogP	4.46
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.634

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: Fmoc-cys-oh
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Fmoc-cys-oh
CAS number:135248-89-4

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C18H17NO4S
Molecular weight:343.4

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

HS Code	2930909090

(Fmoc-Cys-OH)2

CAS#:135273-01-7

~91%

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Han, Yongxin; Barany, George Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 3841 - 3848

Fmoc-Cys(Trt)-OH

CAS#:103213-32-7

~99%

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Postma, Tobias M.; Albericio, Fernando; Giraud, Matthieu Organic Letters, 2012 , vol. 14, # 21 p. 5468 - 5471,4 Title/Abstract Full Text Show Details Postma, Tobias M.; Giraud, Matthieu; Albericio, Fernando Organic Letters, 2012 , vol. 14, # 21 p. 5468 - 5471

L-cysteine

CAS#:52-90-4

N-Fmoc-1H-benzo...

CAS#:1131148-55-4

~69%

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Chemical Biology and Drug Design, 2012 , vol. 80, # 2 p. 194 - 202

4-nitrobenzyl N...

CAS#:1431430-16-8

~93%

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Cui, Hong-Kui; Guo, Ye; He, Yao; Wang, Feng-Liang; Chang, Hao-Nan; Wang, Yu-Jia; Wu, Fang-Ming; Tian, Chang-Lin; Liu, Lei Angewandte Chemie - International Edition, 2013 , vol. 52, # 36 p. 9558 - 9562 Angew. Chem., 2013 , vol. 125, # 36 p. 9737 - 9741,5

(aacaa)2

CAS#:1227363-09-8

9-Fluorenylmeth...

CAS#:28920-43-6

Fmoc-Ala-OH

CAS#:35661-39-3

Fmoc-L-Alanine

CAS#:35661-38-2

Detail

Literature: Mozziconacci, Olivier; Kerwin, Bruce A.; Schoeneich, Christian Journal of Physical Chemistry B, 2010 , vol. 114, # 19 p. 6751 - 6762

(lgacagl)2

CAS#:1227363-07-6

9-Fluorenylmeth...

CAS#:28920-43-6

Fmoc-Gly-OH

CAS#:29022-11-5

Fmoc-Leu-OH

CAS#:35661-60-0

Detail

Literature: Mozziconacci, Olivier; Kerwin, Bruce A.; Schoeneich, Christian Journal of Physical Chemistry B, 2010 , vol. 114, # 19 p. 6751 - 6762

9-Fluorenylmeth...

CAS#:28920-43-6

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Chemical Biology and Drug Design, 2012 , vol. 80, # 2 p. 194 - 202

L-cysteine

CAS#:52-90-4

9-Fluorenylmeth...

CAS#:28920-43-6

Fmoc-L-cysteine

CAS#:135248-89-4

Literature: Zhou, Wei; Zhang, Xiao-Yan; Duan, Geng-Li Journal of the Chinese Chemical Society, 2011 , vol. 58, # 4 p. 509 - 515

Precursor 7
CAS#:135273-01-7 (Fmoc-Cys-OH)2 CAS#:103213-32-7 Fmoc-Cys(Trt)-OH CAS#:52-90-4 L-cysteine CAS#:1131148-55-4 N-Fmoc-1H-benzo...
CAS#:1227363-09-8 (aacaa)2 CAS#:28920-43-6 9-Fluorenylmeth... CAS#:1227363-07-6 (lgacagl)2
DownStream 4
CAS#:186829-25-4 Fmoc-Cys(Xan)-OH CAS#:70-18-8 Glutathione CAS#:247595-29-5 Fmoc-Cys(DPM)-OH CAS#:73724-43-3 Fmoc-Cys(StBu)-OH