hydroflumethiazide

Modify Date: 2024-01-06 00:13:28

hydroflumethiazide structure	Common Name	hydroflumethiazide
	CAS Number	135-09-1	Molecular Weight	331.29200
	Density	1.678g/cm3	Boiling Point	531.6ºC at 760 mmHg
	Molecular Formula	C₈H₈F₃N₃O₄S₂	Melting Point	272-273ºC
	MSDS	Chinese USA	Flash Point	275.3ºC
	Symbol	GHS08	Signal Word	Danger

Use of hydroflumethiazide

Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].

Name	1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Synonym	More Synonyms

Description	Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7. [2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37. [3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9.

Description

Related Catalog

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7.

[2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37.

[3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9.

Density	1.678g/cm3
Boiling Point	531.6ºC at 760 mmHg
Melting Point	272-273ºC
Molecular Formula	C₈H₈F₃N₃O₄S₂
Molecular Weight	331.29200
Flash Point	275.3ºC
Exact Mass	330.99100
PSA	135.12000
LogP	3.34280
Vapour Pressure	2.2E-11mmHg at 25°C
Index of Refraction	1.55
Storage condition	Refrigerator

hydroflumethiazide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK9625000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 135-09-1

BEILSTEIN REFERENCE NO. :: 0342692

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-F3-N3-O4-S2

MOLECULAR WEIGHT :: 331.31

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ HXFFF ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,629,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6280 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1182 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #80M

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H317-H334
Precautionary Statements	P261-P280-P284-P304 + P340-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn,Xi
Risk Phrases	R42/43
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DK9625000
HS Code	2935009090

2,4-disulfamyl-...

CAS#:654-62-6

Formaldehyde

CAS#:50-00-0

hydroflumethiazide

CAS#:135-09-1

Literature: Journal of the American Chemical Society, , vol. 81, p. 4807,4808

5-Amino-α.α.α-t...

CAS#:1479-95-4

hydroflumethiazide

CAS#:135-09-1

Literature: Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135

Formaldehyde

CAS#:50-00-0

5-Amino-α.α.α-t...

CAS#:1479-95-4

hydroflumethiazide

CAS#:135-09-1

Literature: Journal of the American Chemical Society, , vol. 81, p. 4807,4808

Precursor 3
CAS#:654-62-6 2,4-disulfamyl-... CAS#:50-00-0 Formaldehyde CAS#:1479-95-4 5-Amino-α.α.α-t...
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Do thiazides reduce intestinal oxalate absorption?: a study in vitro using rabbit colon.

Clin. Sci. 86(3) , 353-7, (1994)

1. The purpose of the present study was to examine the effects of various diuretics on intestinal oxalate transport. Transmural oxalate fluxes were measured across isolated, short-circuited tissue seg...

Comparative effects of LN 5330 and diazoxide on insulin release and 86Rb+ permeability in perifused rat islets of Langerhans.

Biochem. Pharmacol. 42(4) , 787-91, (1991)

The benzothiadiazine derivative LN 5330 (chloro-7 trifluoromethyl-6 benzothiadiazine-1,2,4-dioxide-1,1) has been shown to inhibit insulin secretion and calcium uptake. The present study was carried ou...

Metabolic effects of propranolol and hydroflumethiazide treatment in Kenyans with mild to moderate essential hypertension.

East Afr. Med. J. 70(11) , 696-700, (1993)

In a prospective single-blind comparative trial, sixty newly diagnosed mild to moderate hypertensives were randomly assigned to either propranolol or hydroflumethiazide monotherapy. Baseline fasting s...

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DC Chemicals Limited
China
Product Name: Hydroflumethiazide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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