OBAA
Modify Date: 2024-01-12 14:38:33
OBAA structure
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Common Name | OBAA | ||
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| CAS Number | 134531-42-3 | Molecular Weight | 428.64700 | |
| Density | 0.974 g/cm3 | Boiling Point | 550.8ºC at 760 mmHg | |
| Molecular Formula | C28H44O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 301ºC | |
Use of OBAAOBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3]. |
| Name | 2-(3-octadecylbenzoyl)prop-2-enoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3]. |
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| Related Catalog | |
| Target |
PLA2:70 nM (IC50) |
| In Vitro | OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1]. |
| In Vivo | The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3]. |
| References |
| Density | 0.974 g/cm3 |
|---|---|
| Boiling Point | 550.8ºC at 760 mmHg |
| Molecular Formula | C28H44O3 |
| Molecular Weight | 428.64700 |
| Flash Point | 301ºC |
| Exact Mass | 428.32900 |
| PSA | 54.37000 |
| LogP | 8.31410 |
| RIDADR | NONH for all modes of transport |
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Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line.
Free Radic. Biol. Med. 39(6) , 769-80, (2005) The barrier functions in epithelial and endothelial cells seem to be very important for maintaining normal biological homeostasis. However, it is unclear whether or how bile acids affect the epithelia... |
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Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid.
Biochem. J. 336 ( Pt 3) , 659-66, (1998) In contrast with mammalian cells, little is known about the control of Ca2+ entry into primitive protozoans. Here we report that Ca2+ influx in pathogenic Trypanosoma brucei can be regulated by phosph... |
| OBAA |
| 4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid 3-(4-octadecyl)benzoylacrylic acid |